1 $ sudo apt-get install cmake cmake-curses-gui gcc g++ git giggle monodevelop see http://www.itk.org/Wiki/ITK/Release_4/SimpleITK/GettingStarted/Visual_guide_to_building_on_Linux also install cmake-qt-gui 2 Get SimpleITK source code: http://sourceforge.net/projects/simpleitk/ 3 Build SimpleITK: $ mkdir Build $ cd Build $ sudo cmake ../SuperBuild Here do not use cmake command line, use cmake-qt-gui, set source and taget, click configure first, and check wrapping for python, uncheck wrapping for Lua, uncheck test 4 Install python2.x-dev 5 In Build, run: $ make This will take a very long time 6 Go to http://pypi.python.org/pypi/ez_setup to download ez_setup 7 Extract ez_setup, in its directory, use: $ sudo python setup.py install $ sudo python distribute_setup.py $ sudo python ez_setup.py to install ez_setup 8 In wrapping, run: $ sudo python PythonPackage/setup.py install 9 Now you should be able to use SimpleITK Python try to type in shell: $ python then type: >>> import SimpleITK